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Start Over Author "Pushie, M. Jake" Journal biochemistry
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1. The structures of the C185S and C185A mutants of sulfite oxidase reveal rearrangement of the active site

Author

Qiu, James A., Wilson, Heather L., Pushie, M. Jake, Kisker, Caroline, George, Graham N., and Rajagopalan, K.V.

Subjects
Alanine -- Chemical properties, Catalysis -- Analysis, Gene mutations -- Analysis, Oxidases -- Chemical properties, Serine -- Chemical properties, Sulfites -- Chemical properties, Biological sciences, Chemistry
Abstract

Serine and alanine variants at position 185 of recombinant chicken SO were generated to better understand the role of reside Cys in the catalytic mechanism of sulfite oxidase. The crystal structures of C185S and C185A variants which contain a fully oxidized, trioxo form of the cofactor, and Tyr322 could undergo a conformational change that is relevant to the reaction mechanism.

Published
2010

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