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Start Over Author "Portugal, Silvia" Journal biochemistry
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1. Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection

Author

Dowling, Daniel P., Ilies, Monica, Olszewski, Kellen L., Portugal, Silvia, Mota, Maria M., Llinas, Manuel, and Christianson, David W.

Subjects
Malaria -- Drug therapy, Plasmodium falciparum -- Physiological aspects, Antimalarials -- Health aspects, Biological sciences, Chemistry
Abstract

Various protein constructs of a parasitic arginase from Plasmodium falciparum were explored to identify an optimally active enzyme form for inhibition and structural studies and to probe the structure and function of two polypeptide insertions unique to malarial arginase. The results suggested that inhibition of malarial arginase might serve as a possible candidate for antimalarial therapy against liver-stage infection, and amino-6-boronohexanoic acid (ABH) might serve as a lead for the development of inhibitors.

Published
2010

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