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Start Over Author "Melis, Riccardo" Journal biochemistry
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1. ATP acts as a regulatory effector in modulating structural transitions of cytochrome c: implications for apoptotic activity

Author

Patriarca, Antonella, Eliseo, Tommaso, Sinibaldi, Federica, Piro, Maria Cristina, Melis, Riccardo, Paci, Maurizio, Cicero, Daniel O., Polticelli, Fabio, Santucci, Roberto, and Fiorucci, Laura

Subjects
Adenosine triphosphate -- Chemical properties, Allosteric enzymes -- Structure, Allosteric enzymes -- Chemical properties, Apoptosis -- Analysis, Cytochrome c -- Chemical properties, Cytochrome c -- Structure, Peroxidase -- Chemical properties, Biological sciences, Chemistry
Abstract

The impact of ATP in modulating the connection between the peroxidase activity and oleic acid-induced conformational transitions of cytochrome c (cyt c) is analyzed. The results demonstrate that ATP can easily be used as an allosteric effector for regulating the structural transitions that are integrated with the apoptotic activity.

Published
2009

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