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Start Over Author "Huston, Ted J." Journal biochemistry
2 results on '"Huston, Ted J."'

1. tRNA-guanine transglycosylase from Escherichia coli is a zinc metalloprotein. Site-directed mutagenesis studies to identify the zinc ligands

Author

Chong, Shaorong, Curnow, Alan W., Huston, Ted J., and Garcia, George A.

Subjects
Escherichia coli -- Research, Metalloproteins -- Genetic aspects, Zinc -- Analysis, Biological sciences, Chemistry
Abstract

Atomic emission spectrometry and site-directed mutagenesis studies of tRNA-guanine transglycosylase (TGT) from Escherichia coli suggest that wild-type TGT possesses 0.8 mol of zinc per molecule of subunit. Cysteines 302, 304 and 307 and histidine 317 are the ligands to the zinc, as suggested by structural probes, enzyme activity and tRNA-binding assays. TGT homodimer formation and tRNA binding require the zinc site.

Published
1995

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