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Start Over Author "Honjo, Eijiro" Journal biochemistry
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1. Thermodynamic analysis of the activation mechanism of the GCSF reception induced by ligand binding

Author

Mine, Shouhei, Koshiba, Takumi, Honjo, Eijiro, Okamoto, Tomoyuki, Tamada, Taro, Yoshitake; Matsukura, Maeda, Yasuko, Horie, Akane, Ishibashi, Matsujiro, Sato, Miharu, Azuma, Mizue, Tokunaga, Masao, Nitta, Katsutoshi, and Kuroki, Ryota

Subjects
Binding proteins -- Analysis, Chemical structure -- Analysis, Granulocyte colony-stimulating factor -- Analysis, Biological sciences, Chemistry
Abstract

The quantitative and structural properties of the interaction of Granulocyte colony-stimulating factor (GCSF) and its receptor were investigated. The thermodyanmic data suggested that the activated structure of the Granulocyte colony-stimulating factor receptor (GCSFR) induced by GCSF binding to Ig-CRH results in the formation of a 2:2 complex structure and the Ig domain would bring each cytokine receptor homologous region (CRH) domain closer and facilitate the interaction of their intracellur domains.

Published
2004

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