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Your search keyword '"Harrison, Rebecca A."' showing total 4 results
Start Over Author "Harrison, Rebecca A." Journal biochemistry
4 results on '"Harrison, Rebecca A."'

1. T cell receptor binding transition states and recognition of peptide/MHC

Author

Davis-Harrison, Rebecca L., Insaidoo, Francis K., and Baker, Brian M.

Subjects
Antigen receptors, T cell -- Structure, Antigen receptors, T cell -- Chemical properties, Major histocompatibility complex -- Structure, Major histocompatibility complex -- Research, Binding proteins -- Structure, Binding proteins -- Research, Protein folding -- Research, T cells -- Receptors, T cells -- Structure, T cells -- Chemical properties, Biological sciences, Chemistry
Abstract

A study analyzes the T cell receptor (TCR) recognition of a peptide bound and presented by a major histocompatibility complex (MHC) molecule, which normally comes about in two steps. The results of the analysis were of great help and will be definitely useful in understanding the nature of the TCR binding transition states, which makes it recognize the composite peptide/MHC surface.

Published
2007

2. Phosphoramidate end labeling of inorganic polyphosphates: facile manipulation of polyphosphate for investigating and modulating its biological activities

Author

Choi, Sharon H., Collins, Julie N.R., Smith, Stephanie A., Davis-Harrison, Rebecca L., Rienstra, Chad M., and Morrissey, James H.

Subjects
Amines -- Chemical properties, Biotin -- Structure, Biotin -- Chemical properties, Nuclear magnetic resonance spectroscopy -- Usage, Phosphates -- Chemical properties, Phosphates -- Structure, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

[Super 31]P NMR was employed to establish that EDAC (1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide)-mediated reactions between primary amines and polyphosphate result in phosphoramidate linkages with the terminal phosphate groups. The findings from the study provide new pathways for the entire armamentarium of protein chemistry to modifying polyphosphate and conduct future studies to understand its biological roles.

Published
2010

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