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Your search keyword '"Datta, Rupak"' showing total 4 results
Start Over Author "Datta, Rupak" Journal biochemistry
4 results on '"Datta, Rupak"'

2. Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: Biological implications

Author

Sen, Baninrata, Venugopal, V., Chakraborty, Anutosh, Datta, Rupak, Dolai, Subhankar, Banerjee, Rahul, and Datta, Alok K.

Subjects
Amino acids -- Chemical properties, Endoplasmic reticulum -- Analysis, Cyclophilin -- Chemical properties, Biological sciences, Chemistry
Abstract

The mechanism of the interaction of endoplasmic reticulum (ER)-located cyclophilin (LdCyP) with adenosine kinase (AdK), which has led to its reactivation, is analyzed. The experiments have shown the importance of the positive charge and have identified R147 as the most vital residue in the LdCyP-AdK interaction, thus providing evidence for the stress-induced retrograde translocation of LdCyP from the ER to the cytoplasm.

Published
2007

3. Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation

Author

Sen, Banibrata, Chakraborty, Anutosh, Datta, Rupak, Bhattacharyya, Debasish, and Datta, Alok K.

Subjects
Adenosine kinase -- Structure, Adenosine kinase -- Properties, Fluorescence spectroscopy -- Analysis, Polarization (Electricity) -- Analysis, Biological sciences, Chemistry
Abstract

Adenosine kinase (AdK), along with its inherent tendency to aggregate by itself, forms large oligomers during the reaction due to the generation of ADP, one of its reaction products. The results show that Leishmania donovani cyclophilin (LdCyP)-induced reactivation occurs due to conformational reorientation of AdK in a manner that decreases the affinity of the enzyme for ADP with consequent relief from the ADP-mediated aggregation.

Published
2006

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