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Start Over Author "Cornes, Michael P." Journal biochemistry
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1. A cross-linking study of the N-terminal extension of human cardiac troponin I

Author

Ward, Douglas G., Brewer, Susan M., Cornes, Michael P., and Trayer, Ian P.

Subjects
Proteins -- Crosslinking, Phosphorylation -- Influence, Phosphorylation -- Analysis, Structure-activity relationships (Biochemistry) -- Analysis, Biological sciences, Chemistry
Abstract

Results show that residues 1-64 of human cardiac troponin 1 binds strongly to C-terminal domain of troponin C and weakly to N-terminal domain, which is further weakened by phosphorylation. Cross-linking studies reveal that the full length of the N-terminal extension in intact troponin is in close proximity to both troponin C and troponin T.

Published
2003

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