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Start Over Author "Bjorge, Jeffrey" Journal biochemistry
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1. Purification of bovine thymus cytosolic C-terminal Src kinase (CSK) and demonstration of differential efficiencies of phosphorylation and inactivation of p56lyn and pp60c-src by CSK

Author

Cheng, Heung-Chin, Bjorge, Jeffrey D., Aebersold, Ruedi, Fujita, Donald J., and Wang, Jerry H.

Subjects
Protein tyrosine kinase -- Analysis, Enzymes -- Structure-activity relationship, Biological sciences, Chemistry
Abstract

The C-terminal src kinase (CSK) isolated from bovine thymus cytosol was characterized by analytic methods. Assays for the protein tyrosine kinase activity of CSK showed that CSK inactivated pp60c-src and p56lyn in increasing efficiency via phosphorylation. The differences in CSK's phosphorylating activity was found to lie on the structural differences between the C-terminal portions of pp60c-src and p56lyn.

Published
1996

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