1. Albumin binding to FcRn: Distinct from the FcRn- IgG interaction
- Author
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Chaudhury, Chaity, Brooks, Charles L., Carter, Daniel C., Robinson, John M., and Anderson, Clark L.
- Subjects
Albumin -- Chemical properties ,Protein binding -- Analysis ,Immunoglobulin G -- Chemical properties ,Decomposition (Chemistry) -- Analysis ,Biological sciences ,Chemistry - Abstract
MHC-related Fc receptor for IgG (FcRn) protects albumin and IgG from degradation by binding both proteins with high affinity at low pH in the acid endosome and diverting both from a lysosomal pathway, returning them to the extracellular compartment. Results suggest that the FcRn-albumin interaction has unique features distinct from FcRn- IgG binding despite the overall similarity in the pH- dependent binding mechanism by which both ligands are protected from degradation.
- Published
- 2006