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Start Over Descriptor "TRIAP1" Journal biochemical society transactions
1 results on '"TRIAP1"'

1. Structural comparison of yeast and human intra-mitochondrial lipid transport systems.

Author

Miliara, Xeni and Matthews, Stephen

Subjects
*LIPID transfer protein, *MITOCHONDRIA formation, *PHOSPHOLIPIDS, *APOPTOSIS, *X-ray crystallography
Abstract

Mitochondria depend on a tightly regulated supply of phospholipids. The protein of relevant evolutionary and lymphoid interest (PRELI)/Ups1 family together with its mitochondrial chaperones [TP53-regulated inhibitor of apoptosis 1 (TRIAP1)/Mdm35] represents a unique heterodimeric lipid-transfer system that is evolutionary conserved from yeast to man. Recent X-ray crystal structures of the human and yeast systems are compared and discuss here and shed new insight into the mechanism of the PRELI/Ups1 system. [ABSTRACT FROM AUTHOR]

Published
2016
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