Search

Your search keyword '"Simpson, R. J."' showing total 32 results
Start Over Author "Simpson, R. J." Journal biochemical society transactions
32 results on '"Simpson, R. J."'

13. Deriving statistical models for predicting peptide tandem MS product ion intensities.

Author

Schütz F, Kapp EA, Simpson RJ, and Speed TP

Subjects
Algorithms, Databases, Protein, Mass Spectrometry methods, Models, Statistical, Peptides chemistry
Abstract

Improved search algorithms and scoring functions are required before the identification of peptide tandem MS data can be considered to be fully reliable and automatable. The development of models that can accurately predict product ion spectra from a peptide sequence would certainly help achieve this goal, but this firstly requires a better understanding of the process of fragmentation of peptides in the gas-phase. We summarize recent developments in this area and show that the prediction of product ion spectra is feasible and should improve the identification of peptide tandem MS data, especially for peptides that currently give low or insignificant scores with current search algorithms.

Published
2003
Full Text
View/download PDF

14. Iron and proton uptake by mouse duodenum.

Author

Simpson RJ and Jafri SE

Subjects
Animals, Carrier Proteins metabolism, Hydrogen-Ion Concentration, Intestinal Mucosa metabolism, Male, Membrane Proteins metabolism, Mice, Protons, Cation Transport Proteins, Duodenum metabolism, Iron metabolism, Iron-Binding Proteins
Published
1998
Full Text
View/download PDF

15. In vitro evidence for mitochondrial effects of indomethacin.

Author

Jacob M, Bjarnason I, and Simpson RJ

Subjects
Animals, In Vitro Techniques, Jejunum drug effects, Jejunum ultrastructure, Male, Microscopy, Electron, Scanning, Mitochondria ultrastructure, Rats, Rats, Sprague-Dawley, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Indomethacin pharmacology, Mitochondria drug effects
Published
1998
Full Text
View/download PDF

18. Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption.

Author

McKie AT, Wehr K, Simpson RJ, Peters TJ, Hentze MW, and Farzaneh F

Subjects
Animals, Cloning, Molecular, Gene Library, Heterozygote, Homozygote, Intestinal Mucosa metabolism, Membrane Proteins deficiency, Membrane Proteins metabolism, Mice, Mice, Mutant Strains, Open Reading Frames, Organ Specificity, Transcription, Genetic, Transferrin deficiency, Transferrin genetics, Duodenum physiology, Intestinal Absorption genetics, Intestinal Mucosa physiology, Iron metabolism, Membrane Proteins genetics
Published
1998
Full Text
View/download PDF

19. Effects of indomethacin on mitochondrial oxygen uptake in intestine.

Author

Jacob M, Bjarnason I, and Simpson RJ

Subjects
2,4-Dinitrophenol pharmacology, Animals, Humans, In Vitro Techniques, Jejunum metabolism, Male, Mitochondria metabolism, Rats, Rats, Sprague-Dawley, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Indomethacin pharmacology, Jejunum drug effects, Mitochondria drug effects, Oxygen metabolism
Published
1998
Full Text
View/download PDF

20. Effects of indomethacin on mitochondrial ATP synthesis.

Author

Jacob M, Bjarnason I, and Simpson RJ

Subjects
Animals, Humans, In Vitro Techniques, Jejunum drug effects, Jejunum metabolism, Male, Mitochondria, Liver metabolism, Rats, Rats, Sprague-Dawley, Adenosine Triphosphate biosynthesis, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Indomethacin pharmacology, Mitochondria, Liver drug effects
Published
1998
Full Text
View/download PDF

22. Nitric oxide: effects on duodenal iron absorption.

Author

Raja KB, Jayasinghe NN, Simpson RJ, and Peters TJ

Subjects
Animals, Cobalt Radioisotopes, Duodenum drug effects, In Vitro Techniques, Iron Radioisotopes, Mice, Nitrates metabolism, Nitrites metabolism, Penicillamine pharmacology, S-Nitroso-N-Acetylpenicillamine, Scintillation Counting, Duodenum physiology, Intestinal Absorption drug effects, Iron metabolism, Nitric Oxide physiology, Penicillamine analogs & derivatives
Published
1997
Full Text
View/download PDF

24. Duodenal expression of NF-E2 in mouse models of altered iron metabolism.

Author

Raja KB, Gerard B, McKie A, Beaumont C, Simpson RJ, Grandchamp B, and Peters TJ

Subjects
Animals, Erythroid-Specific DNA-Binding Factors, Intestinal Absorption, Iron pharmacology, Iron Deficiencies, Mice, Mice, Inbred Strains, NF-E2 Transcription Factor, NF-E2 Transcription Factor, p45 Subunit, Polymerase Chain Reaction, Reference Values, Zinc Fingers, DNA-Binding Proteins biosynthesis, Duodenum, Gene Expression drug effects, Intestinal Mucosa metabolism, Iron metabolism, Transcription Factors biosynthesis
Published
1995
Full Text
View/download PDF

25. Inhibition of duodenal mucosal ferricyanide reductase.

Author

Lazouras K, Pountney D, and Simpson RJ

Subjects
2,4-Dinitrophenol, Animals, Cell Membrane drug effects, Cell Membrane physiology, Dinitrophenols pharmacology, Hypoxia, Membrane Potentials drug effects, Membrane Potentials physiology, Mice, NADH, NADPH Oxidoreductases antagonists & inhibitors, Sodium Fluoride pharmacology, Duodenum, Intestinal Mucosa enzymology, Intestinal Mucosa physiology
Published
1995
Full Text
View/download PDF

26. Duodenal ferric reductase: purification and characterisation.

Author

Pountney DJ, Simpson RJ, and Wrigglesworth JM

Subjects
Animals, Ferricyanides metabolism, Flavin Mononucleotide pharmacology, Humans, In Vitro Techniques, Mice, Microvilli enzymology, NAD metabolism, NADH, NADPH Oxidoreductases metabolism, Oxidation-Reduction, Rabbits, Duodenum enzymology, FMN Reductase, NADH, NADPH Oxidoreductases isolation & purification
Published
1994
Full Text
View/download PDF

30. Iron chelate affinity chromatography of brush border membrane proteins.

Author

Simpson RJ, Raja KB, and Shah T

Subjects
Animals, Chromatography, Affinity methods, Electrophoresis, Polyacrylamide Gel, Ferric Compounds metabolism, Intestine, Small metabolism, Iron metabolism, Iron-Binding Proteins, Mice, Microvilli metabolism, Molecular Weight, Nitrilotriacetic Acid analogs & derivatives, Nitrilotriacetic Acid metabolism, Rabbits, Rats, Species Specificity, Transferrin-Binding Proteins, Carrier Proteins isolation & purification, Intestine, Small chemistry, Membrane Proteins isolation & purification, Microvilli chemistry
Published
1992
Full Text
View/download PDF

31. Molecular cloning of human and rabbit UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.

Author

Schachter H, Hull E, Sarkar M, Simpson RJ, Moritz RL, Höppener JW, and Dunn R

Subjects
Amino Acid Sequence, Animals, Blotting, Southern, Carbohydrate Sequence, Cloning, Molecular, DNA genetics, Gene Library, Humans, Molecular Sequence Data, Rabbits, Glucosyltransferases genetics, Liver enzymology, N-Acetylglucosaminyltransferases
Published
1991
Full Text
View/download PDF

32. Ferric iron reduction and uptake by mouse duodenal mucosa.

Author

Raja KB, Simpson RJ, and Peters TJ

Subjects
Animals, Biological Transport drug effects, Ferricyanides pharmacology, Ferrozine pharmacology, In Vitro Techniques, Intestinal Mucosa drug effects, Iron Radioisotopes, Kinetics, Mice, Oxidation-Reduction, Duodenum metabolism, Intestinal Mucosa metabolism, Iron metabolism
Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results