1. Advances in TERS (tip-enhanced Raman scattering) for biochemical applications
- Author
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Regina Treffer, Volker Deckert, Stephan Tiede, René Böhme, Tanja Deckert-Gaudig, Xiumei Lin, and Katherine Lau
- Subjects
Chemistry ,Resolution (electron density) ,Nanotechnology ,DNA ,Spectrum Analysis, Raman ,Biochemistry ,Characterization (materials science) ,symbols.namesake ,RNA analysis ,symbols ,RNA ,Spectrum analysis ,Raman scattering - Abstract
TERS (tip-enhanced Raman scattering) provides exceptional spatial resolution without any need for labelling and has become a versatile tool for biochemical analysis. Two examples will be highlighted here. On the one hand, TERS measurements on a single mitochondrion are discussed, monitoring the oxidation state of the central iron ion of cytochrome c, leading towards a single protein characterization scheme in a natural environment. On the other hand, a novel approach of single molecule analysis is discussed, again based on TERS experiments on DNA and RNA, further highlighting the resolution capabilities of this method.
- Published
- 2012