Search

Your search keyword '"P. Scott Pine"' showing total 2 results
Start Over Author "P. Scott Pine" Journal biochemical pharmacology
2 results on '"P. Scott Pine"'

1. Behavior of N-acylated daunorubicins in MDR1 gene transfected and parental cells

Author

P. Scott Pine, Michael M. Gottesman, Ramesh C. Pandey, and Adorjan Aszalos

Subjects
Daunorubicin, Biology, Transfection, Biochemistry, law.invention, Mice, Confocal microscopy, law, Complementary DNA, Tumor Cells, Cultured, polycyclic compounds, medicine, Animals, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, neoplasms, Pharmacology, Dose-Response Relationship, Drug, Cell growth, Substrate (chemistry), 3T3 Cells, Drug Resistance, Multiple, Membrane, Cell culture, Cyclosporine, Cell Division, medicine.drug
Abstract

The substrate specificity of the P-glycoprotein (P-170), a multidrug transporter, was studied using N-acylated daunorubicin derivatives and four MDR1 cDNA transfected cell lines. Results showed that N-acetyl-daunorubicin is a substrate, but the longer fatty acid derivatives, N-octanoyl and N-dodecanoyl daunorubicins, are not. This conclusion was reached by flow cytometric drug uptake assay, cell proliferation assays, and confocal microscopy. It was concluded that the longer fatty acid derivatives interact with plasma membranes in a way that affected P-glycoprotein function.

Published
1995

2. Prevention of binding of rgp120 by anti-HIV active tannins

Author

P. Scott Pine, Kuo Hsing Lee, Adorjan Aszalos, Yung-Chi Cheng, James L. Weaver, and Ginger E. Dutschman

Subjects
Chebulinic acid, Lymphocyte, Human immunodeficiency virus (HIV), Biology, HIV Envelope Protein gp120, medicine.disease_cause, Biochemistry, Antiviral Agents, Virus, chemistry.chemical_compound, medicine, Tannin, Humans, Lymphocytes, Pharmacology, chemistry.chemical_classification, Anti hiv, Punicalin, Recombinant Proteins, medicine.anatomical_structure, chemistry, Nat, Drug Design, CD4 Antigens, Tannins, Protein Binding
Abstract

Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587-595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgp120 to CD4. These compounds were not toxic to stimulated human peripheral blood lymphocytes at concentrations ten times above their maximal effective concentration.

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results