1. Biogenesis, trafficking and up-regulation of nicotinic ACh receptors.
- Author
-
Colombo SF, Mazzo F, Pistillo F, and Gotti C
- Subjects
- Animals, Cell Membrane, Neurons physiology, Protein Conformation, Receptors, Nicotinic classification, Receptors, Nicotinic genetics, Protein Transport physiology, Receptors, Nicotinic metabolism, Up-Regulation physiology
- Abstract
Chronic nicotine exposure gives rise to neural adaptations that change whole cell physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine receptors (nAChRs). The major nicotine-induced neuroadaptation is the up-regulation of brain nAChRs by means of cell-delimited post-translational mechanisms. We review what is known of the processes regulating nAChR assembly, degradation and trafficking, and how nicotine-induced modulation of these processes leads to nAChR up-regulation and changes in downstream neuronal plasticity at molecular, cellular and circuit level., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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