1. AMP-aminohydrolase of human skeletal muscle: the inhibitory effect of alanine
- Author
-
Krystian Kaletha, Andrzej Stankiewicz, and Mariusz Zydowo
- Subjects
Alanine ,Chemistry ,Potassium ,Muscles ,Skeletal muscle ,Substrate (chemistry) ,chemistry.chemical_element ,AMP deaminase ,Metabolism ,Biochemistry ,AMP Deaminase ,Potassium Chloride ,Enzyme Activation ,Enzyme activator ,Kinetics ,medicine.anatomical_structure ,Nucleotide Deaminases ,medicine ,Humans ,Incubation - Abstract
1. 1. Alanine, a significant substance that takes part in skeletal muscle metabolism, has been found to inhibit human skeletal muscle AMP-aminohydrolase activity. 2. 2. The type and the degree of this inhibition depends on the KCl concentration in the incubation medium. At a low KCl concentration (7 m m ) the inhibition by alanine occurred at all substrate concentrations tested (from 0.04 to 1.0 m m ), whereas at a higher KCl concentration ∗ (150 m m ) the inhibition was found only at lower concentrations of AMP. 3. 3. A possible metabolic significance of the inhibitory effect of alanine on AMP-aminohydrolase activity is briefly discussed.
- Published
- 1976