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Start Over Author "L. Żelewski" Journal biochemical medicine
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1. Regulation of progesterone from 20 alpha-dihydroprogesterone biosynthesis by phosphopyridine nucleotides in the human placental mitochondrial fraction

Author

J. Klimek and L. Żelewski

Subjects
chemistry.chemical_classification, Placenta, Dehydrogenase, Mitochondrion, Biology, 20α-Dihydroprogesterone, NAD, Biochemistry, Redox, Enzyme assay, 20-alpha-Dihydroprogesterone, Mitochondria, chemistry.chemical_compound, Biosynthesis, chemistry, Pregnancy, biology.protein, Humans, Nucleotide, Female, NAD+ kinase, 20-Hydroxysteroid Dehydrogenases, NADP, Progesterone
Abstract

In human term placental mitochondria the equilibrium rate of the reaction catalyzed by 20α-hydroxysteroid dehydrogenase was shown to be shifted to progesterone formation. The enzyme activity was more specific for NAD+ than NADP+. NADH strongly inhibited the progesterone biosynthesis from 20α-dihydroprogesterone. This inhibition could be reversed by the conditions with favor the NADH oxidation. Regulation of progesterone biosynthesis by the redox state of phosphopyridine nucleotides in human placental mitochondria is discussed.

Published
1980

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