1. ENZYMIC CONVERSION OF 3-HYDROXYANTHRANILIC ACID INTO CINNABARINIC ACID BY THE NUCLEAR FRACTION OF RAT LIVER
- Author
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Subbarao Pv, Jegannathan Ns, and Vaidyanathan Cs
- Subjects
Silver ,Stereochemistry ,Iron ,General Mathematics ,3-Hydroxyanthranilic Acid ,Benzoates ,Arsenicals ,chemistry.chemical_compound ,Oxazines ,Anthranilic acid ,ortho-Aminobenzoates ,Cysteine ,Enzyme Inhibitors ,3-Hydroxyanthranilic acid ,Cell Nucleus ,Molybdenum ,Pharmacology ,chemistry.chemical_classification ,biology ,Research ,Applied Mathematics ,Articles ,Mercury ,Glutathione ,Metabolism ,biology.organism_classification ,Rats ,Enzyme ,Liver ,chemistry ,Biochemistry ,Hydroxymercuribenzoates ,Spinach ,Liver function ,Oxidoreductases ,Copper - Abstract
Although several authors have implicated 3-hydroxyanthranilic acid (3-OHA) as an intermediate in tryptophaniacin pathway in animals (Kaplan, 1961), alternative pathways of metabolism of this compound have not been fully explored. Madhusudanan Nair obtained an enzyme from spinach leaves which could convert 3-OHA to cinnabarinic acid (private communication). Viollier and Sullmann (1950) reported the conversion of 3-OHA to an unidentified red compound by rat liver homogenates. The present investigation describes the identification of this product as cinnabarinic acid (2-amino-3-H-isophenoxazine-3-one-1,9-dicarboxylic acid). Cinnabarinic acid is known to occur in nature along with cinnabarin is olated from the fungus Polystictus sanguineus (Gripenberg et al., 1957; Gripenberg, 1958).
- Published
- 1965
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