1. Disturbance of lysosomal glycogen metabolism by liposomal anti-alpha-glucosidase and some anti-inflammatory drugs.
- Author
-
Geddes R, Otter DE, Scott GK, and Taylor JA
- Subjects
- Acarbose, Animals, Antibodies immunology, Glucose metabolism, In Vitro Techniques, Liposomes administration & dosage, Lysosomes drug effects, Male, Molecular Weight, Rats, Rats, Inbred Strains, Salicylic Acid, Trisaccharides immunology, Glucosidases antagonists & inhibitors, Glycoside Hydrolase Inhibitors, Indomethacin pharmacology, Liver Glycogen metabolism, Lysosomes metabolism, Oligosaccharides pharmacology, Salicylates pharmacology, Trisaccharides pharmacology
- Abstract
The size-distribution of liver glycogen was shown to be distinctly affected by the anti-inflammatory drugs salicylate and indomethacin. By measurement of the incorporation of radioactive glucose into glycogen, salicylate was shown to have a depressing effect on overall liver glycogen metabolism. These effects appear to arise from the stabilizing of the lysosome by the drugs. The incorporation, via liposomes, of purified anti-1,4-alpha-glucosidase activity and in the content of high-molecular-weight glycogen. These changes are increased by prolonged liposomal antibody treatment and suggest that a possible feedback control mechanism operates in the incorporation of glycogen into lysosomes. These experiments may be useful as a model of glycogen turnover and its failure in glycogenosis type II (Pompe's disease).
- Published
- 1983
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