1. Different allelic distribution of a single SNP between sexes in humans
- Author
-
Daniela Cigognini, Pasquale Tripputi, Stefano Bianchi, and Luigi Fedele
- Subjects
Adult ,Male ,Linkage disequilibrium ,medicine.medical_specialty ,Heterozygote ,Genotype ,Receptors, Antigen, T-Cell, alpha-beta ,Single-nucleotide polymorphism ,Biology ,Biochemistry ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,Genetics ,medicine ,SNP ,Humans ,Allele ,Molecular Biology ,Allele frequency ,Ecology, Evolution, Behavior and Systematics ,Homozygote ,Heterozygote advantage ,General Medicine ,Middle Aged ,Endocrinology ,Female - Abstract
We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (chi2 = 8.799, P = 0.012).
- Published
- 2007