1. Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle
- Author
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Jae Sung Hwang, Yong-Cheol Park, Dae-Hyuk Kweon, Jun Seob Kim, Joo Sung Yang, Jin-Ho Seo, Jae Yoon Shin, Dongwoo Shin, Yoosoo Yang, Yunha Hwang, Jae Il Shin, and Yong Su Jin
- Subjects
Coenzyme Q10 ,Liposome ,Nanostructure ,Apolipoprotein A-I ,Ubiquinone ,Biophysics ,Nanoparticle ,Water ,Nanotechnology ,Cell Biology ,Biochemistry ,chemistry.chemical_compound ,Discoidal high-density lipoprotein particle ,chemistry ,Solubility ,Acyl chain ,Phosphatidylcholines ,Water chemistry ,Nanoparticles ,lipids (amino acids, peptides, and proteins) ,Particle size ,Particle Size ,Lipoproteins, HDL ,Molecular Biology - Abstract
There are tremendous drug candidates that suffer from insolubility in water. In the present study, it is shown that Coenzyme Q10 (CoQ10), a model water-insoluble compound, can be nanoparticulated into a water-soluble form using apolipoprotein A-I (apoA-I). Similar to the way that apoA-I forms nascent discoidal high density lipoprotein (ndHDL) particles by bordering acyl chain tails of phospholipids, CoQ10 could be enclosed into the circle of a disk made of apoA-Is. The resulting nanostructure of CoQ10 and apoA-I was water-soluble with a size of approximately 12 nm in diameter and was physically more robust than liposome. We expect that the strategy suggested in this study can be exploited to assemble nano-sized, water-soluble structures of various water-insoluble drug candidates.
- Published
- 2009