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Start Over Author "Kim, Sun Jung" Journal biochemical and biophysical research communications
6 results on '"Kim, Sun Jung"'

6. Analysis of cag-8: a novel poly(Q)-encoding gene in the mouse brain.

Author

Ji JW, Yang HL, and Kim SJ

Subjects
Alternative Splicing, Amino Acid Sequence, Animals, Base Sequence, DNA, Complementary analysis, Mice, Molecular Sequence Data, Nerve Tissue Proteins genetics, Peptides genetics, Subcellular Fractions, Brain metabolism, Nerve Tissue Proteins metabolism, Peptides metabolism, Promoter Regions, Genetic physiology
Abstract

We identified 13 transcript isoforms of a trinucleotide-repeat-containing gene, cag-8, that is expressed almost exclusively in the mouse brain. The polypeptide deduced from the cDNA consists of 137 AAs, of which 74 are glutamines. The 130-kb gene is composed of 16 exons, from which at least 13 isoforms with variable UTRs are formed by alternative splicing. A strong positive cis-acting element was found in the neuroblastomaxglioma hybrid NG108-15 and human embryonic kidney HEK293 cell lines. The cag-8 protein was localized in the cytosol and in granular bodies within the nucleus. These findings indicate that cag-8 is a novel poly(Q)-encoding gene, the expression of which is confined primarily to the brain.

Published
2006
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