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Start Over Author "Cowieson, Nathan" Journal biochemical & biophysical research communications
1 results on '"Cowieson, Nathan"'

1. Combined pressure and temperature denaturation of ribonuclease A produces alternate denatured states.

Author

Ryan, Timothy M., Xun, Yun, Cowieson, Nathan P., Mata, Jitendra P., Jackson, Andrew, Pauw, Brian R., Smith, Andrew J., Kirby, Nigel, and McGillivray, Duncan

Subjects
*RIBONUCLEASE A, *PROTEIN folding, *PROTEIN structure, *DENATURATION of proteins, *HIGH temperatures, *SMALL-angle scattering
Abstract

Protein folding, unfolding and misfolding have become critically important to a range of health and industry applications. Increasing high temperature and high pressure are used to control and speed up reactions. A number of studies have indicated that these parameters can have a large effecton protein structure and function. Here we describe the additive effects of these parameters on the small angle scattering behaviour of ribonuclease A. We find that alternate unfolded structures can be obtained with combined high pressure and temperature treatment of the protein. [ABSTRACT FROM AUTHOR]

Published
2016
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