1. Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance
- Author
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Li, Jipeng, Wang, Yiping, Yu, Wanjun, Chen, Jun, and Luo, Jianping
- Subjects
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GENE expression , *SERUM , *LIVER cancer , *CELL differentiation , *CANCER cells , *GENETIC regulation , *CANCER patients , *PROGNOSIS - Abstract
Abstract: Objective: To investigate whether the serum miR-221 expression correlates with clinicopathologic features and the prognosis of hepatocellular carcinoma (HCC) patients. Methods: Four miRNAs (miR-221, miR-222, miR-21 and miR-224) related to HCC were selected in the present study. Serum miRNA expression was investigated in 46 HCC patients and 20 healthy normal controls by using real-time PCR technique, and then correlations between miR-221 expression and the clinicopathological features and prognosis of HCC patients were evaluated. Results: The four miRNAs were found to be differentially overexpressed in HCC serum samples, and high level of miR-221 expression was correlated with tumor size (P <0.001), cirrhosis (P =0.003) and tumor stage (P =0.016). In addition, Kaplan–Meier survival analysis showed that the overall survival rate of the high miR-221 expression group (27.6%) was significantly lower than that of the low miR-221 expression group (62.3%, P <0.05). Conclusions: Serum miR-221, upregulated in HCC, can provide predictive significance for prognosis of HCC patients. [Copyright &y& Elsevier]
- Published
- 2011
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