1. Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells.
- Author
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Lui, Eric Lik-Hang, Ao, Carl Ka-Leong, Li, Lina, Khong, Mei-Li, and Tanner, Julian Alexander
- Subjects
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INORGANIC polyphosphates , *INTERLEUKIN-11 , *CELL migration , *CELLULAR signal transduction , *PROTEIN expression , *GENE expression - Abstract
Polyphosphate (polyP) is abundant in bone but its roles in signaling and control of gene expression remain unclear. Here, we investigate the effect of extracellular polyP on proliferation, migration, apoptosis, gene and protein expression in human osteoblast-like SaOS-2 cells. Extracellular polyP promoted SaOS-2 cell proliferation, increased rates of migration, inhibited apoptosis and stimulated the rapid phosphorylation of extracellular-signal-regulated kinase (ERK) directly through basic fibroblast growth factor receptor (bFGFR). cDNA microarray revealed that polyP induced significant upregulation of interleukin 11 (IL-11) at both RNA and protein levels. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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