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Objective:High concentrations of nitric oxide cause a neurotoxic effect on nerve action potentials. Although glucocorticoids can decrease that effect, the degree of mediation is not known. This study determined the effect of dexamethasone on frog sciatic nerve axon fibers subjected to in vitro oxidative stress.Methods:Frog sciatic nerves were isolated into Groups: -Control Group-incubation in Ringer’s solution; SNP Group- incubation in 10-² M sodium nitroprusside solution; SNP+DEX Group-incubation in 10-² M sodium nitroprusside solution followed by incubation in 10-³ M dexamethasone solution; DEX group- incubation in 10-³ M dexamethasone solution.Results:In the SNP group, significant changes were observed in the action potential velocity of propagation (p

Catecholamines play a regulatory role in the cardiovascular system, primarily via β (1-2)-adrenoreceptors (AR). However, in the late 1980s, the cloning of a third β-AR subtype (β3-AR) in the heart has altered the conventional view on the regulation of heart function via the beta-adrenergic receptors. Additionally, in blood vessels, β3-AR was shown to produce relaxation. Currently, the physiological role of β3-AR is not clearly known. Hence, the purpose of this review is to summarize the physiological evidences supporting the functional roles of β3-AR in various tissues, particularly cardiac and vascular. In addition, this review discusses the potential role of β3-AR in obesity and insulin resistance and emphasizes their putative involvement as new therapeutic targets.