1. The coagulopathy in acute promyelocytic leukaemia--what have we learned in the past twenty years.
- Author
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Kwaan HC and Cull EH
- Subjects
- Annexin A2 blood, Anticoagulants therapeutic use, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Arsenic Trioxide, Arsenicals pharmacology, Arsenicals therapeutic use, Blood Coagulation Disorders drug therapy, Blood Coagulation Tests, Carboxypeptidase B2 deficiency, Disseminated Intravascular Coagulation etiology, Fibrinolysis, Forecasting, Granulocyte Precursor Cells metabolism, Hemorrhagic Disorders drug therapy, Hemorrhagic Disorders etiology, Humans, Leukemia, Promyelocytic, Acute complications, Leukemia, Promyelocytic, Acute drug therapy, Oxides pharmacology, Oxides therapeutic use, Recombinant Proteins therapeutic use, Risk Factors, S100 Proteins blood, Thrombomodulin therapeutic use, Thrombophilia drug therapy, Thrombophilia etiology, Thromboplastin metabolism, Tretinoin therapeutic use, Urokinase-Type Plasminogen Activator blood, Blood Coagulation Disorders etiology, Leukemia, Promyelocytic, Acute blood
- Abstract
Coagulopathy is a unique component of the pathology of acute promyelocytic leukaemia (APL). Though many causative factors have been elucidated, therapies to rectify the coagulopathy are far from being realised. Thrombotic and bleeding complications remain the major causes of early deaths. In this chapter, the known causes of abnormalities in haemostatic function, namely the coagulopathy and changes in the fibrinolytic system, will be reviewed. Major risk factors for these complications are identified. Current available measures for correction of the coagulopathy and their effectiveness are critically examined. Unless the coagulopathy can be effectively controlled, bleeding complications will remain an obstacle to achieving a cure for this disease. The issues that need to be addressed in next phase of investigations are also discussed., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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