Search

Your search keyword '"Bergman, Jack"' showing total 138 results
Start Over Author "Bergman, Jack" Journal behavioural pharmacology
138 results on '"Bergman, Jack"'

7. Altered sleep during spontaneous cannabinoid withdrawal in male mice

Author

Missig, Galen, primary, Mehta, Niyati, additional, Robbins, James O., additional, Good, Cameron H., additional, Iliopoulos-Tsoutsouvas, Christos, additional, Makriyannis, Alex, additional, Nikas, Spyros P., additional, Bergman, Jack, additional, Carlezon, William A., additional, and Paronis, Carol A., additional

Published
2022
Full Text
View/download PDF

26. The pharmacology of executive functioning

Author

Vanderschuren Louk, Willner Paul, Ellenbroek Bart, and Bergman Jack

Subjects
Pharmacology, Psychiatry and Mental health, Medical education, Executive Function, MEDLINE, Humans, Psychology, Introductory Journal Article
Published
2018

32. The behavioural pharmacology of the basal ganglia: in memory of Lex Cools

Author

Willner, Paul, Bergman, Jack, Vanderschuren, Louk, Ellenbroek, Bart, Sub Neurobiologie van gedrag, ASS E&C1, and Emotion and Cognition

Subjects
Pharmacology, biology, Methylphenidate, Dopaminergic, Cognition, Striatum, behavioral disciplines and activities, Basal Ganglia, Psychiatry and Mental health, Neuroimaging, Basal ganglia, Taverne, biology.protein, medicine, Animals, Humans, Allele, Psychology, Neuroscience, Dopamine transporter, medicine.drug
Abstract

Attention-deficit/hyperactivity disorder (ADHD) is accompanied by impairments in cognitive control, such as task-switching deficits. We investigated whether such problems, and their remediation by medication, reflect abnormal reward motivation and associated striatal dopamine transmission in ADHD. We used functional genetic neuroimaging to assess the effects of dopaminergic medication and reward motivation on task-switching and striatal BOLD signal in 23 adults with ADHD, ON and OFF methylphenidate, and 26 healthy controls. Critically, we took into account interindividual variability in striatal dopamine by exploiting a common genetic polymorphism (3'-UTR VNTR) in the DAT1 gene coding for the dopamine transporter. The results showed a highly significant group by genotype interaction in the striatum. This was because a subgroup of patients with ADHD showed markedly exaggerated effects of reward on the striatal BOLD signal during task-switching when they were OFF their dopaminergic medication. Specifically, patients carrying the 9R allele showed a greater striatal signal than healthy controls carrying this allele, whereas no effect of diagnosis was observed in 10R homozygotes. Aberrant striatal responses were normalized when 9R-carrying patients with ADHD were ON medication. These pilot data indicate an important role for aberrant reward motivation, striatal dopamine and interindividual genetic differences in cognitive processes in adult ADHD. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results