Search

Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. However, when amphetamine is used to treat distractibility, it is given chronically, yet no data exist on whether chronic amphetamine treatment affects the colliculus. Here, the effect of chronic amphetamine treatment was assessed in healthy hooded lister rats on two collicular dependent behaviours following a twenty-eight day treatment period: i) orienting to visual stimuli, and ii) height-dependent modulation of air-righting. We found no significant impact of amphetamine treatment on visual orienting despite showing dose-dependent decreases in orienting to repeated stimuli. However, we did find that treatment with amphetamine significantly reduced the ability to modulate righting according to the height the animal is dropped from - a function known to be dependent on the colliculus. We suggest that the results are in line with previous research showing acute amphetamine suppresses collicular activity and we speculate that the psychostimulant may increase receptive field size, altering time-to-impact calculations carried out by the colliculus during air-righting.

On the Carousel maze, rats are trained to avoid a sector of a circular rotating arena, punishable by a mild electric foot-shock. In the room frame (RF) variant, the punishable sector remains stable relative to the room, while in the arena frame (AF) version, the sector rotates with the arena. The rats therefore need to disregard local olfactory, tactile and self-motion cues in RF condition and distal extra-maze landmarks in the AF task. In both primates and rodents, the coordination of various spatial reference frames is thought to depend on the posterior parietal cortex (PPC). We have previously shown that PPC-lesioned rats can solve both variants of the Carousel avoidance task. Here we aimed to determine the effects of bilateral thermocoagulation lesion of the PPC in Long-Evans rats on the ability to transition between multiple spatial strategies. The rats were first trained in five sessions in one condition and then another five sessions in the other. The following training schemes were used: RF to AF, RF to RF reversal (sector on the opposite side), and AF to RF. We found a PPC lesion-associated impairment in the transition from the AF to RF task, but not vice versa. Furthermore, PPC lesion impaired performance in RF reversal. In accordance to the literature, we also found an impairment in navigation guided by intra-maze visuospatial cues, but not by extra-maze cues in the water maze. Therefore, the PPC lesion-induced impairment is neither specific to distant cues nor to allocentric processing. Our results thus indicate a role of the PPC in the flexibility in spatial behaviors guided by visual orientation cues.

The behavioral capacities of the rhesus monkey for several sensory and cognitive tasks appear quite similar to those of humans. To evaluate the monkey's attentional capacities, we have compared monkey and human performance on a visuospatial attentional task, the cued target detection (CTD) paradigm. Animals were trained to fixate a small spot of light while a cue and a subsequent target, are flashed in the visual periphery. In valid trials, the cue and target appeared in the same spatial location; in invalid trials, the cue and target appeared in the opposite location; in double trials, two cues were presented and the target appeared in one of their locations; in no-cue trials, the cue was omitted and the target appeared in one location. In addition, we varied cognitive control over the task initiation by making the trial onset either self-paced or computer-paced. Reaction times (RTs) to target presentation, response accuracy, and frequency of aborted trials were measured for all subjects. No significant species differences were found for the patterns of RTs for different trial types or for attentional dynamics, as indexed by the decreases in RT with increasing cue-target interval. However, humans and non-human primates reacted differently to changes in cognitive control. Humans shows significant increases in no-cue trial RTs in the auto-paced task compared to the self-paced, but no differences in overall RT between tasks; monkeys showed a significant faster overall RT for the self-paced than the computer-paced task, but no difference between no-cue RTs. The performance differences between species may be related to the training history of the animals or to known anatomical differences in cortical organization, especially in the parietal lobe.

We have studied the visual prey acquisition behavior of frogs with unilateral optic nerve section, unilateral tectal lobe ablation, and unilateral transverse hemisection at a level between the tectum and the cerebellum. The first two groups of animals oriented normally to stimuli throughout the region of visual field overlap and failed to respond to more peripheral stimuli on one side. Hemisected animals responded to stimuli at all positions in the visual field. For stimuli located contralateral to the lesion, the frogs oriented normally. For ipsilateral stimuli, the frogs oriented forward.

The visual behavior of gerbils has been studied by adapting natural behaviors such as food pursuit, aperture detection, barrier negotiation and ladder climbing. Methods are described for measuring detection and discrimination thresholds using visual orienting tasks. Furthermore, studies of size-distance constancy, anticipation of a moving target's trajectory, and optimal planning of barrier detours show the usefulness of film records for quantitative analysis of complex perceptual abilities. Finally, preliminary studies of gerbils following ablation of primary visual cortex indicate that some visuomotor abilities are cortically dependent.

Rats with bilateral ablation of the superior colliculus (SC) were compared with sham-operated rats in two experiments. In the first, it was found that discrimination performance deteriorated as a function of S-R separation, to a similar extent in both groups. In this experiment, unlike earlier ones which found a deficit, the separation was introduced in a horizontal direction. In the second experiment, spatial orientation in the Morris Swimming Pool was found to be impaired in the SC rats both when the target platform was visible and when invisible. During their presence on the platform, these rats also engaged less often in upward orienting movements, although horizontal movements were of normal frequency. It is proposed (i) that there is an anisotropy in the SC's control of orienting head and eye movements in rats, and (ii) that the swimming pool deficit may be due to an impairment of ambient vision.

Pigeons were trained to perform a visual orientation invariance task consisting of shape matching-to-sample or oddity-from-sample discriminations where the comparison forms differed in orientation from the sample forms, and the odd comparison forms were always a mirror image of the sample. They then received lesions affecting the visual projection area within the anterior hyperstriatum or the dorsal neostriatum, a control area with no known visual function. Both groups of birds evinced minor transient postoperative deficits of similar magnitude during the shape recognition task under orientation invariance conditions when the habitual training forms were used. When novel forms were introduced, the performance of hyperstriatal pigeons was significantly worse than that of the neostriatal pigeons, but still well above chance. The introduction of a delay between the offset of the sample and the onset of the habitual comparison stimuli did not yield any differential effect. It is concluded that orientation invariance of pattern recognition performance of birds, in contrast to that in mammals, is probably a midbrain, optic tectum function.