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Your search keyword '"Paula Santana"' showing total 5 results
Start Over Author "Paula Santana" Journal behavioural brain research
5 results on '"Paula Santana"'

1. Exploring the role of environmental enrichment and early life adversity on emotional development

Author

de Lima, Randriely Merscher Sobreira, da Mata, Martielo Januario, Santos, Josefa Cristina Pereira dos, Costa, Ludhielle, Marques, Victor Hugo Moreira, Bento, Lucas Victor dos Santos, Lugon, Marcelo di Marcello Valladão, Arcego, Danusa Mar, Barauna, Valério Garrone, Bittencourt, Athelson Stefanon, and Bittencourt, Ana Paula Santana de Vasconcellos

Published
2024
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3. Early life stress and the programming of eating behavior and anxiety: Sex-specific relationships with serotonergic activity and hypothalamic neuropeptides

Author

de Lima, Randriely Merscher Sobreira, primary, dos Santos Bento, Lucas Victor, additional, di Marcello Valladão Lugon, Marcelo, additional, Barauna, Valerio Garrone, additional, Bittencourt, Athelson Stefanon, additional, Dalmaz, Carla, additional, and de Vasconcellos Bittencourt, Ana Paula Santana, additional

Published
2020
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4. Early life stress and the programming of eating behavior and anxiety: Sex-specific relationships with serotonergic activity and hypothalamic neuropeptides

Author

Randriely Merscher Sobreira de Lima, Lucas Victor dos Santos Bento, Valério Garrone Barauna, Athelson Stefanon Bittencourt, Marcelo di Marcello Valladão Lugon, Carla Dalmaz, and Ana Paula Santana de Vasconcellos Bittencourt

Subjects
Male, medicine.medical_specialty, Serotonin, Pro-Opiomelanocortin, media_common.quotation_subject, Hypothalamus, Nerve Tissue Proteins, Anxiety, Serotonergic, Amygdala, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Internal medicine, medicine, Animals, Neuropeptide Y, Rats, Wistar, 030304 developmental biology, media_common, 0303 health sciences, Maternal deprivation, Sex Characteristics, Leptin receptor, Behavior, Animal, business.industry, Maternal Deprivation, digestive, oral, and skin physiology, Appetite, Feeding Behavior, Resilience, Psychological, medicine.disease, Rats, Eating disorders, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, Anxiogenic, Animals, Newborn, Receptors, Leptin, Female, business, 030217 neurology & neurosurgery, Stress, Psychological
Abstract

Early life experiences have strong influences on brain programming and can affect eating behavior control and body weight later in life. However, there is no consensus about the relationship between neonatal stress and feeding behavior. We evaluated whether maternal deprivation (MD) and maternal separation (MS) alter body weight and appetite using standard rat chow consumption and palatable food. Also, we evaluated anxiety and the expression of the leptin receptor, neuropeptides POMC, CART, NPY in the hypothalamus, as well as the serotoninergic system in the amygdala and hypothalamus as possible modulators of these behaviors. We found a decrease in standard rat chow consumption in MD. However, both neonatal stress protocols increased the consumption of palatable food and led to anxiogenic behavior in male animals. MD led to decreased hypothalamic POMC levels in adult males. Serotonin in the hypothalamus was decreased by both stress models in males and females. In the amygdala, MS decreased serotonin levels while MD increased its metabolite levels. We observed that males are more vulnerable and females are more resilient to the effects of neonatal stress on anxiety-like behavior, as well as on food consumption and on the central changes observed. These data together add support to the concept that the early environment contributes to the development of eating disorders later in life.

Published
2019

5. Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia.

Author

Biasibetti R, Tramontina AC, Costa AP, Dutra MF, Quincozes-Santos A, Nardin P, Bernardi CL, Wartchow KM, Lunardi PS, and Gonçalves CA

Subjects
Animals, Catechin pharmacology, Cognition drug effects, Glial Fibrillary Acidic Protein metabolism, Glucose metabolism, Glutathione metabolism, Glutathione Peroxidase metabolism, Hippocampus drug effects, Hippocampus metabolism, Injections, Intraventricular, Male, Maze Learning drug effects, Nerve Growth Factors metabolism, Neuroglia metabolism, Nitric Oxide metabolism, Rats, Rats, Wistar, Reactive Oxygen Species metabolism, S100 Calcium Binding Protein beta Subunit, S100 Proteins metabolism, Space Perception drug effects, Acetylcholinesterase metabolism, Antibiotics, Antineoplastic administration & dosage, Antioxidants pharmacology, Catechin analogs & derivatives, Dementia chemically induced, Dementia metabolism, Neuroprotective Agents, Oxidative Stress drug effects, Streptozocin administration & dosage, Tea chemistry
Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia. Intracerebroventricular (ICV) infusion of streptozotocin (STZ) provides a relevant animal model of chronic brain dysfunction that is characterized by long-term and progressive deficits in learning, memory, and cognitive behavior, along with a permanent and ongoing cerebral energy deficit. Numerous studies on green tea epigallocatechin gallate (EGCG) demonstrate its beneficial effects on cognition and memory. As such, this study evaluated, for the first time, the effects of sub-chronic EGCG treatment in rats that were submitted to ICV infusion of STZ (3mg/kg). Male Wistar rats were divided into sham, STZ, sham+EGCG and STZ+EGCG groups. EGCG was administered at a dose of 10mg/kg/day for 4 weeks per gavage. Learning and memory was evaluated using Morris' Water Maze. Oxidative stress markers and involvement of the nitric oxide (NO) system, acetylcholinesterase activity (AChE) and glucose uptake were evaluated as well as glial parameters including S100B content and secretion and GFAP content. Our results show that EGCG was not able to modify glucose uptake and glutathione content, although cognitive deficit, S100B content and secretion, AChE activity, glutathione peroxidase activity, NO metabolites, and reactive oxygen species content were completely reversed by EGCG administration, confirming the neuroprotective potential of this compound. These findings contribute to the understanding of diseases accompanied by cognitive deficits and the STZ-model of dementia., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
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