1. A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats
- Author
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Jonathan P. Beck, Joanna C. Neill, Samantha L. McLean, and Marie L. Woolley
- Subjects
medicine.medical_specialty ,Psychosis ,medicine.drug_class ,Phencyclidine ,Atypical antipsychotic ,Pilot Projects ,Drug Administration Schedule ,Statistics, Nonparametric ,Behavioral Neuroscience ,Sex Factors ,Internal medicine ,medicine ,Haloperidol ,Animals ,Attention ,Drug Interactions ,Habituation, Psychophysiologic ,Psychiatry ,Clozapine ,Cognitive deficit ,Risperidone ,Dose-Response Relationship, Drug ,Dopamine antagonist ,Rats, Inbred Strains ,medicine.disease ,Rats ,Endocrinology ,Set, Psychology ,Female ,medicine.symptom ,Psychology ,Excitatory Amino Acid Antagonists ,Antipsychotic Agents ,medicine.drug - Abstract
RATIONALE: The NMDA receptor antagonist, phencyclidine (PCP), has been shown to induce symptoms characteristic of schizophrenia. A loss in executive function and the ability to shift attention between stimulus dimensions is impaired in schizophrenia; this can be assessed in rodents by the perceptual attentional set-shifting task. OBJECTIVE: The aim of this study was to investigate whether the deficits induced by sub-chronic PCP in attentional set-shifting could be reversed by sub-chronic administration of clozapine, risperidone or haloperidol. METHODS: Adult female hooded-Lister rats received sub-chronic PCP (2 mg/kg) or vehicle (1 ml/kg) i.p. twice daily for 7 days, followed by a 7-day washout period. PCP-treated rats then received clozapine, risperidone, haloperidol or vehicle once daily for 7 days and were then tested in the perceptual set-shifting task. RESULTS: PCP significantly (p
- Published
- 2008