1. Temporal and qualitative dynamics of conditioned taste aversion processing: combined generalization testing and licking microstructure analysis.
- Author
-
Baird JP, St John SJ, and Nguyen EA
- Subjects
- Analysis of Variance, Animals, Avoidance Learning drug effects, Behavior, Animal drug effects, Behavior, Animal physiology, Conditioning, Psychological drug effects, Dose-Response Relationship, Drug, Drinking drug effects, Drinking physiology, Drinking Behavior drug effects, Generalization, Psychological drug effects, Lithium Chloride administration & dosage, Male, Rats, Rats, Sprague-Dawley, Sodium Chloride administration & dosage, Sucrose administration & dosage, Time Factors, Avoidance Learning physiology, Conditioning, Psychological physiology, Drinking Behavior physiology, Generalization, Psychological physiology, Taste
- Abstract
The pattern of licking microstructure during various phases of a conditioned taste aversion (CTA) was evaluated. In Experiment 1, rats ingested lithium chloride (LiCl) for 3 trials and were then offered sodium chloride (NaCl) or sucrose on 3 trials. A CTA to LiCl developed and generalized to NaCl but not to sucrose. CTA intake suppression was characterized by reductions in burst size, average ingestion rate, and intraburst lick rate, and increases in brief pauses and burst counts. Compared with previous studies, LiCl licking shifted from a pattern initially matching that for normally accepted NaCl to one matching licking for normally avoided quinine hydrochloride by the end of the 1st acquisition trial. In Experiment 2, a novel paradigm was developed to show that rats expressed CTA generalization within 9 min of their first LiCl access. These results suggest that licking microstructure analysis can be used to assay changes in hedonic evaluation caused by treatments that produce aversive states., ((c) 2005 APA)
- Published
- 2005
- Full Text
- View/download PDF