1. Pemoline: Enhancement of maze performance in young rats
- Author
-
Nicholas P. Plotnikoff
- Subjects
Male ,Epinephrine ,Dopamine ,Receptors, Drug ,Pemoline ,Methyltyrosines ,Dopaminergic mechanisms ,Safety margin ,Pharmacology ,Discrimination Learning ,Lethal Dose 50 ,Memory ,Avoidance Learning ,Reaction Time ,medicine ,Animals ,Problem Solving ,General Environmental Science ,Brain Chemistry ,Electroshock ,Age Factors ,Housing, Animal ,Rats ,Toxicity ,General Earth and Planetary Sciences ,Performance enhancement ,Psychology ,medicine.drug - Abstract
The present study demonstrates that pemoline enhances performance of acquisition in a maze test in young immature rats. Toxicity studies in such rats indicate a wide safety margin. The mechanism of this performance enhancement by pemoline was proposed to be via dopaminergic mechanisms since the psychostimulant effects were prevented by a-methyl-p-tyrosine, a known depletor of brain catechol amines.
- Published
- 1973
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