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Your search keyword '"DeFries, John C."' showing total 27 results
Start Over Author "DeFries, John C." Journal behavior genetics
27 results on '"DeFries, John C."'

17. Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity.

Author

Thomas, Aimee L., Evans, Luke M., Nelsen, Michaela D., Chesler, Elissa J., Powers, Matthew S., Booher, Winona C., Lowry, Christopher A., DeFries, John C., and Ehringer, Marissa A.

Subjects
NUCLEOTIDE sequencing, FUNCTIONAL genomics, SEQUENCE analysis, FUNCTIONAL analysis, KNOCKOUT mice, DNA
Abstract

We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA variants that differed between their BALB/cJ and C57BL/6J parental strains. Next, we assessed genome-wide sharing (3,678,826 variants) both between and within the High and Low Activity strains. Results suggested that about 10% of these DNA variants may be associated with OFA, and clearly demonstrated its polygenic nature. Finally, we conducted bioinformatic analyses of functional genomics data from mouse, rat, and human to refine previously identified quantitative trait loci (QTL) for anxiety-related measures. This combination of sequence analysis and genomic-data integration facilitated refinement of previously intractable QTL findings, and identified possible genes for functional follow-up studies. [ABSTRACT FROM AUTHOR]

Published
2021
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27. DNA Evidence for Strong Genome-Wide Pleiotropy of Cognitive and Learning Abilities

Author

Trzaskowski, Maciej, Davis, Oliver S. P., DeFries, John C., Yang, Jian, Visscher, Peter M., and Plomin, Robert

Subjects
Genetic Markers, Male, Intelligence, Twins, Neuropsychological Tests, Heritability, Cognition, Genetics, Humans, Learning, Genetics(clinical), Longitudinal Studies, Learning abilities, Child, Ecology, Evolution, Behavior and Systematics, Original Research, Language, Pleiotropy, Intelligence Tests, GCTA, Wales, Genome, Human, Genetic Pleiotropy, DNA, England, Multivariate Analysis, Female, Mathematics, Genome-Wide Association Study
Abstract

Very different neurocognitive processes appear to be involved in cognitive abilities such as verbal and non-verbal ability as compared to learning abilities taught in schools such as reading and mathematics. However, twin studies that compare similarity for monozygotic and dizygotic twins suggest that the same genes are largely responsible for genetic influence on these diverse aspects of cognitive function. It is now possible to test this evidence for strong pleiotropy using DNA alone from samples of unrelated individuals. Here we used this new method with 1.7 million DNA markers for a sample of 2,500 unrelated children at age 12 to investigate for the first time the extent of pleiotropy between general cognitive ability (aka intelligence) and learning abilities (reading, mathematics and language skills). We also compared these DNA results to results from twin analyses using the same sample and measures. The DNA-based method revealed strong genome-wide pleiotropy: Genetic correlations were greater than 0.70 between general cognitive ability and language, reading, and mathematics, results that were highly similar to twin study estimates of genetic correlations. These results indicate that genes related to diverse neurocognitive processes have general rather than specific effects.

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