1. Effects of Seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers.
- Author
-
Saruwatari J, Takashima A, Yoshida K, Soraoka H, Ding TB, Uchiyashiki Y, Tsuda Y, Imamura M, Oniki K, Miyata K, and Nakagawa K
- Subjects
- Adult, Arylamine N-Acetyltransferase metabolism, Asian People, Caffeine administration & dosage, Cytochrome P-450 CYP1A2 metabolism, Cytochrome P-450 CYP2D6 metabolism, Cytochrome P-450 CYP3A metabolism, Dextromethorphan administration & dosage, Healthy Volunteers, Herb-Drug Interactions, Humans, Hydrocortisone analogs & derivatives, Hydrocortisone urine, Male, Plants, Medicinal chemistry, Xanthine Oxidase metabolism, Young Adult, Furocoumarins pharmacology, Herbal Medicine, Medicine, Traditional, Phytotherapy
- Abstract
Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, healthy, non-smoking males were assessed for the baseline activity of cytochrome P450 (CYP) 1A2, CYP3A, CYP2D6, N-acetyltransferase 2 and xanthine oxidase according to the urinary metabolic indices of 8-hr urine samples collected after the administration of a 150-mg dose of caffeine and a 30-mg dose of dextromethorphan, and the ratio of urinary excretion of 6β-hydroxycortisol to cortisol. Thereafter, the volunteers received 3.75 g of seijo-bofu-to twice daily for 7 days and underwent the same tests on post-dose day 7. The geometric mean ratio of the CYP1A2 activity on day 7 to that observed at baseline was 0.66 (95% CI, 0.55-0.79, p = 0.001). The geometric mean phenotypic indices for CYP3A, CYP2D6, N-acetyltransferase 2 and xanthine oxidase on day 7 did not differ from the baseline values. The findings of the present study suggest that seijo-bofu-to may inhibit the activity of CYP1A2, whereas it is unlikely to participate in herb-drug interactions involving medications predominantly metabolized by CYP3A, CYP2D6, N-acetyltransferase 2 or xanthine oxidase., (© 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).)
- Published
- 2014
- Full Text
- View/download PDF