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Your search keyword '"Shu-bo Chen"' showing total 2 results
Start Over Author "Shu-bo Chen" Journal bangladesh journal of pharmacology
2 results on '"Shu-bo Chen"'

1. Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

Author

Meng Hang, Fan Zhao, Shu-Bo Chen, Qing Sun, and Chun-Xiao Zhang

Subjects
Epithelial-Mesenchymal Transition, Kaempferol, Non-small cell lung cancer, Therapeutics. Pharmacology, RM1-950
Abstract

The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.

Published
2015
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2. Kaempferol modulates the metastasis of human non-small cell lung cancer cells by inhibiting epithelial-mesenchymal transition

Author

Chun-Xiao Zhang, Fan Zhao, Shu-Bo Chen, Meng Hang, and Qing Sun

Subjects
Oncology, medicine.medical_specialty, Epithelial-Mesenchymal Transition, Flavonoid, Vimentin, Metastasis, Kaempferol, chemistry.chemical_compound, Non-small cell lung cancer, Internal medicine, medicine, Epithelial–mesenchymal transition, Lung cancer, Pharmacology, chemistry.chemical_classification, Transition (genetics), biology, lcsh:RM1-950, medicine.disease, lcsh:Therapeutics. Pharmacology, chemistry, Cancer research, biology.protein, Non small cell
Abstract

The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migration in a dose-dependent manner but also modulated the expression of EMT-related proteins E-cadherin and vimentin which are indispensible to cellular motility, invasiveness and metastasis. These results indicate that kaempferol suppresses non-small cell lung cancer migration by modulating the expression of EMT proteins. Therefore, kaempferol may be useful as a potential anticancer agent for non-small cell lung cancer.

Published
2015

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