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Introduction: Vascular leiomyomas or angioleiomyomas are rare benign tumors of the soft muscles within blood vessels, which are usually found in the lower extremities in females. Case Presentation: In this case report, we discuss a rare case of subcutaneous vascular leiomyoma of the right knee of a forty-nine-year-old woman who presented with increasing anterior right knee pain and soft tissue swelling. Clinical findings, plain radiographic, ultrasonography and histopathologic findings of the tumor are discussed. Conclusion: This paper reinforces that angioleiomyomas are rarely diagnosed by clinical features alone, and imaging modalities are essential for early detection and excision. [ABSTRACT FROM AUTHOR]