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Your search keyword '"Nice, Edouard C."' showing total 7 results
Start Over Author "Nice, Edouard C." Journal autophagy
7 results on '"Nice, Edouard C."'

1. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Author

Jiang, Jingwen, primary, Zhang, Lu, additional, Chen, Haining, additional, Lei, Yunlong, additional, Zhang, Tao, additional, Wang, Yuelong, additional, Jin, Ping, additional, Lan, Jiang, additional, Zhou, Li, additional, Huang, Zhao, additional, Li, Bowen, additional, Liu, Yuan, additional, Gao, Wei, additional, Xie, Ke, additional, Zhou, Liangxue, additional, Nice, Edouard C., additional, Peng, Yong, additional, Cao, Yihai, additional, Wei, Yuquan, additional, Wang, Kui, additional, and Huang, Canhua, additional

Published
2019
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2. Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux

Author

Wang, Kui, primary, Zhang, Tao, additional, Lei, Yunlong, additional, Li, Xuefeng, additional, Jiang, Jingwen, additional, Lan, Jiang, additional, Liu, Yuan, additional, Chen, Haining, additional, Gao, Wei, additional, Xie, Na, additional, Chen, Qiang, additional, Zhu, Xiaofeng, additional, Liu, Xiang, additional, Xie, Ke, additional, Peng, Yong, additional, Nice, Edouard C., additional, Wu, Min, additional, Huang, Canhua, additional, and Wei, Yuquan, additional

Published
2018
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3. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.

Author

Jiang, Jingwen, Zhang, Lu, Chen, Haining, Lei, Yunlong, Zhang, Tao, Wang, Yuelong, Jin, Ping, Lan, Jiang, Zhou, Li, Huang, Zhao, Li, Bowen, Liu, Yuan, Gao, Wei, Xie, Ke, Zhou, Liangxue, Nice, Edouard C., Peng, Yong, Cao, Yihai, Wei, Yuquan, and Wang, Kui

Abstract

GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic efficacy over temozolomide, the first-line chemotherapeutic agent for GBM treatment both in vitro and in vivo. Mechanistically, regorafenib directly stabilizes PSAT1 (phosphoserine aminotransferase 1), a critical enzyme for serine synthesis, to trigger PRKAA-dependent autophagy initiation and inhibit RAB11A-mediated autophagosome-lysosome fusion, resulting in lethal autophagy arrest in GBM cells. Maintenance of PSAT1 at a high level is essential for regorafenib-induced GBM suppression. Together, our data provide novel mechanistic insights of regorafenib-induced autophagy arrest and suggest a new paradigm for effective treatment of GBM. Abbreviations: 3-MA: 3-methyladenine; ACACA: acetyl coenzyme A carboxylase alpha; ACTB/β-actin: actin, beta; AMPK: adenosine monophosphate-activated protein kinase; ATG5: autophagy related 5; CTSD: cathepsin D; DN-: dominant-negative; GBM: glioblastoma multiforme; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PRKAA/AMPKα: protein kinase AMP-activated catalytic subunit alpha; PSAT1: phosphoserine aminotransferase 1; SQSTM1/p62: sequestosome 1; TKIs: tyrosine kinase inhibitors. [ABSTRACT FROM AUTHOR]

Published
2020
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5. PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation

Author

Xie, Na, primary, Yuan, Kefei, additional, Zhou, Li, additional, Wang, Kui, additional, Chen, Hai-Ning, additional, Lei, Yunlong, additional, Lan, Jiang, additional, Pu, Qinqin, additional, Gao, Wei, additional, Zhang, Lu, additional, Shen, Guobo, additional, Li, Qifu, additional, Xiao, Hengyi, additional, Tang, Hong, additional, Xiang, Rong, additional, He, Mingliang, additional, Feng, Pinghui, additional, Nice, Edouard C., additional, Wei, Yuquan, additional, Zhang, Haiyuan, additional, Yang, Jiayin, additional, and Huang, Canhua, additional

Published
2016
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6. Itraconazole suppresses the growth of glioblastoma through induction of autophagy

Author

Liu, Rui, primary, Li, Jingyi, additional, Zhang, Tao, additional, Zou, Linzhi, additional, Chen, Yi, additional, Wang, Kui, additional, Lei, Yunlong, additional, Yuan, Kefei, additional, Li, Yi, additional, Lan, Jiang, additional, Cheng, Lin, additional, Xie, Na, additional, Xiang, Rong, additional, Nice, Edouard C, additional, Huang, Canhua, additional, and Wei, Yuquan, additional

Published
2014
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