1. Regulation of cell death by sphingosine 1-phosphate lyase
- Author
-
Thierry Levade, Nathalie Andrieu-Abadie, Patrice Codogno, Sandra Colié, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Signalisation et physiopathologie des cellules épithéliales, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Simon, Marie Francoise
- Subjects
MESH: Aldehyde-Lyases ,MESH: Cell Death ,Programmed cell death ,Regulator ,Biology ,MESH: Mice, Knockout ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Downregulation and upregulation ,[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Autophagy ,MESH: Autophagy ,Animals ,Homeostasis ,MESH: Animals ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,MESH: Mice ,Molecular Biology ,Aldehyde-Lyases ,030304 developmental biology ,Mice, Knockout ,0303 health sciences ,Cell Death ,Sphingosine ,Catabolism ,organic chemicals ,Cell Biology ,Cell biology ,chemistry ,MESH: Homeostasis ,Apoptosis ,Cancer cell ,lipids (amino acids, peptides, and proteins) ,030217 neurology & neurosurgery - Abstract
International audience; By controlling sphingosine 1-phosphate (S1P) catabolism, S1P lyase (SPL) represents an undeniable candidate as potential regulator of a cancer cell's fate in response to stress. Our recent study reveals that complete loss of SPL activity leads to upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL and consequently protects against apoptosis induced by chemotherapy and nutrient starvation but not against autophagy. Here, we speculate on how S1P and disruption of S1P breakdown may regulate cell death and autophagy.
- Published
- 2010