1. Pregnancy outcome predictors in antiphospholipid syndrome: A systematic review and meta-analysis
- Author
-
Katharina Wilhelmina Maria Bloemenkamp, Maarten Limper, Anne Titia Lely, Mirthe Jasmijn Klein Haneveld, Isabel Johanna Walter, and Judith Kooiman
- Subjects
Lupus anticoagulant ,medicine.medical_specialty ,Pregnancy ,Obstetrics ,business.industry ,Immunology ,Infant, Newborn ,Pregnancy Outcome ,Odds ratio ,medicine.disease ,Antiphospholipid Syndrome ,Preeclampsia ,Pre-Eclampsia ,Antiphospholipid syndrome ,Meta-analysis ,Lupus Coagulation Inhibitor ,medicine ,Immunology and Allergy ,Small for gestational age ,Humans ,Premature Birth ,Female ,Live birth ,business - Abstract
OBJECTIVE To identify and assess the magnitude of effect of pregnancy outcome predictors in women with antiphospholipid syndrome (APS) by means of systematic review and meta-analysis. METHODS PubMed and Embase were searched (13th June 2020) for studies reporting on pre-pregnancy risk factors of pregnancy outcomes in APS patients. Literature screening and data extraction were conducted by two reviewers independently, in a blinded standardized manner. Pooled univariate odds ratios (OR) were computed using a random effects model. Heterogeneity was assessed by I2%. RESULTS The search yielded 3013 unique results; 27 records were included in this meta-analysis. Previous thrombosis was associated with a decreased live birth risk (OR 0.60, p
- Published
- 2021