1. The late news on baff in autoimmune diseases
- Author
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Pierre Youinou, Jacques-Olivier Pers, Michel, Geneviève, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Laboratoire d'Immunologie et Immunothérapie, and Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)
- Subjects
[SDV.IMM] Life Sciences [q-bio]/Immunology ,MESH: Feedback, Physiological ,medicine.medical_treatment ,Immunology ,Autoimmunity ,MESH: Protein Isoforms ,Biology ,Autoimmune Diseases ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,immune system diseases ,B cell homeostasis ,MESH: Autoimmune Diseases ,MESH: B-Lymphocytes ,hemic and lymphatic diseases ,MESH: Autoimmunity ,B-Cell Activating Factor ,medicine ,Animals ,Homeostasis ,Humans ,Protein Isoforms ,Immunology and Allergy ,MESH: Animals ,MESH: B-Cell Activating Factor ,skin and connective tissue diseases ,B-cell activating factor ,Overproduction ,030304 developmental biology ,Feedback, Physiological ,B-Lymphocytes ,0303 health sciences ,MESH: Humans ,MESH: Alternative Splicing ,3. Good health ,Alternative Splicing ,stomatognathic diseases ,Cytokine ,MESH: Homeostasis ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Splice isoforms ,030215 immunology - Abstract
International audience; The B cell-activating factor of the tumor-necrosis factor family (BAFF) plays a dominant role in the B cell homeostasis. By rescuing autoreactive B cells, excessive BAFF favors the development of autoimmune diseases. Given the numbers of variants of this B cell-specific cytokine, caution must be exercized when determining its serum level. Alternate splice isoforms, such as Δ3 BAFF and Δ4 BAFF, have been identified. They raise the possibility that their overproduction impact the synthesis of full-length BAFF.
- Published
- 2010
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