1. Course monitoring of membranous nephropathy: Both autoantibodies and podocytes require multidimensional attention
- Author
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Baoli Liu, Haikun Hu, Guiyang Huo, Jie Geng, Yujiao Huang, Anlong Xu, Wenbin Liu, Guangrui Huang, and Hongliang Rui
- Subjects
business.industry ,Podocytes ,Receptors, Phospholipase A2 ,Immunology ,Autoantibody ,Autoimmune responses ,Disease ,Precision medicine ,medicine.disease ,Glomerulonephritis, Membranous ,Podocyte ,Pathogenesis ,medicine.anatomical_structure ,Antigen ,Membranous nephropathy ,Immunology and Allergy ,Medicine ,Humans ,Attention ,business ,Autoantibodies - Abstract
A variety of podocyte antigens have been identified in human membranous nephropathy (MN), which is divided into various antigen-dominated subtypes, confirming the concept that MN is the common pattern of glomerular injury in multiple autoimmune responses. The detection of autoantibodies has been widely used, which promoted the clinical practice of MN toward personalized precision medicine. However, given the potential risks of immunosuppressive therapy, more autoantibodies and biomarkers need to be identified to predict the prognosis and therapeutic response of MN more accurately. In this review, we attempted to summarize the autoantigens/autoantibodies and autoimmune mechanisms that can predict disease states based on the current understanding of MN pathogenesis, especially the podocyte injury manifestations. In conclusion, both the autoimmune response and podocyte injury require multidimensional attention in the disease course of MN.
- Published
- 2021