1. Prophylaxis against venous thrombosis after total hip arthroplasty.
- Author
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Feller JA, Parkin JD, Phillips GW, Hannon PJ, Hennessy O, and Huggins RM
- Subjects
- Anesthesia, General statistics & numerical data, Anesthesia, Spinal statistics & numerical data, Double-Blind Method, Drug Evaluation, Humans, Incidence, Postoperative Complications diagnostic imaging, Postoperative Complications epidemiology, Radiography, Regression Analysis, Thrombophlebitis diagnostic imaging, Thrombophlebitis epidemiology, Warfarin administration & dosage, Hip Prosthesis statistics & numerical data, Postoperative Complications prevention & control, Thrombophlebitis prevention & control
- Abstract
Venous thrombosis rates were compared in 200 patients undergoing total hip arthroplasty and randomized to receive either fixed mini-dose warfarin (1 mg daily) or adjusted-dose warfarin to maintain an international normalized prothrombin ratio (INR) of 2.0-4.0. Bilateral lower limb venography was performed between days 11 and 13 inclusive. Fixed mini-dose warfarin was associated with a significantly higher rate of total thrombosis (P less than 0.05). General anaesthesia was associated with a significantly higher rate of thrombosis than spinal anaesthesia (P less than 0.05). Adjusted-dose warfarin was associated with more bleeding complications than mini-dose warfarin although these were not attributable to excessive anticoagulation. A single death from pulmonary embolus occurred in the early postoperative period in a patient receiving adjusted-dose warfarin.
- Published
- 1992
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