1. Distinct profiles of psychological and neuropsychological functions underlying goal-directed pursuit in schizophrenia.
- Author
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Gerritsen CJ, Goldberg JO, Kiang M, Remington G, Foussias G, and Eastwood JD
- Subjects
- Humans, Schizophrenic Psychology, Goals, Motivation, Reward, Neuropsychological Tests, Schizophrenia diagnosis
- Abstract
Objectives: Several components are known to underlie goal-directed pursuit, including executive, motivational and volitional functions. These were explored in schizophrenia spectrum disorders in order to identify subgroups with distinct profiles., Methods: Multiple executive, motivational and volitional tests were administered to a sample of outpatients with schizophrenia spectrum diagnoses ( n = 59) and controls ( n = 63). Research questions included whether distinct profiles exist and whether some functions are impacted disproportionately. These questions were addressed via cluster analysis and profile analysis, respectively., Results: Some such functions were significantly altered in schizophrenia while others were unaffected. Two distinct profiles emerged, one characterized by energizing deficits, reduced reward sensitivity and few subjective complaints; while another was characterized by markedly increased punishment sensitivity, intact reward sensitivity and substantial subjective reporting of avolitional symptoms and boredom susceptibility., Conclusion: These findings highlight the importance of considering distinct patterns of strengths and deficits in functions governing goal-directed pursuit in schizophrenia that demarcate identifiable subtypes. These distinctions have implications for treatment, assessment and research.
- Published
- 2022
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