1. Topical Nigella Sativa for nasal symptoms in elderly.
- Author
-
Oysu, Cagatay, Tosun, Ahmet, Yilmaz, Huseyin Baki, Sahin-Yilmaz, Asli, Korkmaz, Deniz, and Karaaslan, Ahmet
- Subjects
- *
BLACK cumin , *NASAL manifestations of general diseases , *NOSE diseases , *NIGELLA , *NASAL mucosa , *OLDER people , *RANDOMIZED controlled trials , *THERAPEUTICS - Abstract
Abstract: Objective: To compare the effects of intranasal application of black seed (Nigella Sativa) oil (NSO) and isotonic sodium chloride solution (ISCS) on nasal symptoms of the elderly. Methods: In this prospective, crossover randomized controlled trial, 42 geriatric patients with nasal dryness and related symptoms were randomized to receive either 2 weeks of isotonic sodium chloride solution (ISCS) followed by 2 weeks of N. sativa oil (NG oil) or the same treatment in the opposite order. There was a washout period of 3 weeks in between the treatment periods. Subjective symptoms including nasal dryness, burning, obstruction, itching and crusting were evaluated by a visual analog scale. Mucociliary function was evaluated with saccharin test. Results: Nasal dryness, obstruction and crusting improved significantly with the use of NSO compared to ISCS without any evidence of relevant carryover effects (p <0.05 for all for the difference in treatment). There was no significant difference between the effect of NSO and ISCS on nasal burning and itching (p >0.05 for all). There was no change in mucociliary clearance during any of the treatment periods. Conclusion: NSO is a better alternative to ISCS to treat nasal mucosa symptoms due to aging. [Copyright &y& Elsevier]
- Published
- 2014
- Full Text
- View/download PDF