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(1) Background: The association of radon-222 with lung cancer is well studied. The aim of the study was to validate a model of indoor radon measurements, to apply radon software to estimate lung cancer cases that are attributable to radon and to study the relationship between radon and earthquakes. (2) Methods: Different data detectors were used to obtain radon measurements in different places. Continuous data collection and predictions of indoor radon concentrations were carried out. Software was used to assess radon-attributable lung cancer cases, and data related to earthquake magnitudes were downloaded from Italian Vulcanology Institute. (3) Results: As expected, the highest radon concentrations were observed on the ground floor (232 ± 232 Bq/m3), with higher values measured during winter than in other seasons. The comparison of the detectors showed the overlapping of the two detectors-measured data sets. The cases of lung cancer that were attributable to radon in Locorotondo were studied (3.66/10,000). From the multivariate analysis of the relationship between high radon concentrations and high earthquake magnitude values, they show statistically significant ORs of just over 1. (4) Conclusions: Although the measured values are, on average, within the reference level, prevention measures must be implemented, as the measured radon values allow us to estimate an expected value of 3.66 cases of lung cancer per 10,000 people in the resident population.