Future projection of drought vulnerability is vital for northern provinces of Iran, including North Khorasan, Khorasan-Razavi, and South Khorasan, due to the highly dependent of their economy on agriculture. The study is motivated by the fact that no research has been conducted to project the future Drought Vulnerability Index (DVI). DVI consist of three components of exposure, sensitivity, and adaptation capacity. More exposure levels of drought, higher sensitivity value, and lower adaptation capacity lead to a higher amount of vulnerability. Combined ERA-Interim-observation meteorological data, CMIP5 models under RCP4.5 and RCP8.5 scenarios, and national census data are used to estimate DVI in the past and future periods. CanESM2, GFDL-ESM2M, and CNRM-CM5 General Circulation Model (GCM) are selected from CMIP5 based on Taylor diagram results. The delta-change technique was selected for statistical downscaling of GCM outputs because it is most widely used. The study period is regarded as 1986–2005 as observation and four future 20-years periods during 2021–2100. Results indicated that the dissipation of the class of “very low” vulnerability is eminent in the near future period of 2021–2040 under the RCP4.5 scenario, and all provinces would experience a new worse class of “very high” vulnerability at 2081–2100, both under RCP4.5 and RCP8.5 scenarios.