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Precipitation plays a dominant role in regulating terrestrial carbon fluxes. In concert with global warming, aridity has been increasing during recent decades in most parts of the world. How global terrestrial carbon fluxes respond to this change, however, is still unclear. Using a remote-sensing-driven, process-based model, the Boreal Ecosystem Productivity Simulator (BEPS), this study investigated the responses of global terrestrial carbon fluxes to meteorological drought, which were characterized by the standardized precipitation evapotranspiration index (SPEI). The results showed that the response of terrestrial carbon fluxes to drought exhibited distinguishable spatial heterogeneity. In most regions, terrestrial carbon fluxes responded strongly to drought. With an increase in annual water balance (annual precipitation minus annual potential evapotranspiration), the response of carbon fluxes to drought became weaker. The lagged time of terrestrial carbon fluxes responding to drought decreased with the increasing strength of carbon fluxes in response to drought. The sensitivity of terrestrial carbon fluxes to drought also showed noticeable spatial heterogeneity. With an increase in annual water balance, the sensitivity first increased and then decreased. Terrestrial carbon fluxes exhibited the highest sensitivity to drought in semi-arid areas. [ABSTRACT FROM AUTHOR]