1. Dynamics and plasticity of chromosome ends: consequences in human pathologies
- Author
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Frédérique Magdinier, Amina Boussouar, Alexandre Ottaviani, Amadou Bah, Caroline Schluth-Bolard, and Eric Gilson
- Subjects
Genetics ,Cancer Research ,Oncology ,Chromosome ,Human genome ,Hematology ,Biology ,Subtelomere ,Genome ,Multiple pathologies ,Telomere - Abstract
In eukaryotic cells, chromosome ends of linear chro mosomes are particular regions of the genome formed by telomeres at the very end and subtelomeres, complex sequences that separate telomeres from chromosome-specific r egions. These two regions are highly dynamic are contribute to th e stability and integrity of the human genome. Furt hermore, in human cells, dysregulation of these regions are imp licated in a wide range of physiological events and pathological manifestations. Due to the amount of information av ailable on the biology of telomeres, we will give a n overview and discuss here what is currently known of the regulat ion of telomere length and homeostasis and describe the complex organization of subtelomeric regions and their impl ication in multiple pathologies.
- Published
- 2011
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