1. Apolipoprotein E genotype and the cardiovascular disease risk phenotype: Impact of sex and adiposity (the FINGEN study)
- Author
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Kofler, Bettina M., Miles, Elizabeth A., Curtis, Peter, Armah, Christopher K., Tricon, Sabine, Grew, Jilly, Napper, Frances L., Farrell, Leslie, Lietz, Georg, Packard, Christopher J., Caslake, Muriel J., Mathers, John C., Williams, Christine M., Calder, Philip C., and Minihane, Anne Marie
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APOLIPOPROTEIN E gene , *PHENOTYPES , *OBESITY , *CARDIOVASCULAR diseases , *LOW density lipoproteins , *BODY mass index - Abstract
Abstract: Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype×BMI/age/sex interactions. APOE genotype had a significant impact on fasting total:LDL-cholesterol (TC:LDL-C) ratio, triglycerides, % HDL3, and the Framingham 10-year CVD risk score (P <0.05), with an overall trend towards lower and higher risk in E2- and E4-carriers, respectively, relative to the wild-type E3/E3 genotype. A greater impact of genotype on TC:HDL-C was observed in females, which explained 16% of the variability in this outcome versus 6% in males. APOE genotype was also associated with plasma C-reactive protein and adhesion molecule concentrations (P <0.05), with significant genotype×BMI interactions observed. Our observations indicate that the association between the APOE genotype and CHD risk is unlikely to be homogenous and highlights the risk of inaccurate estimations of genotype–phenotype associations in population subgroups without appropriate stratification for sex and adiposity. [Copyright &y& Elsevier]
- Published
- 2012
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